Disruption of Visual representations and Brain-Wide neural dynamics following psilocybin administration(Openscope)
Nilesh Jain · Pankaj Gupta
Project Description
Psychedelics are known to alter perception, sensory integration, and cortical network dynamics, yet the mechanisms by which they reshape visual representations across distributed cortical populations remain poorly understood. This project investigates how psilocybin changes neural encoding of natural images, inter-neuronal correlation structure, functional connectivity, neural manifolds, and behavioral state in mice. By integrating Neuropixels recordings with eye tracking, pupil dynamics, locomotion, and behavioral measurements from the Allen Institute OpenScope PsyCode dataset, we aim to characterize how psychedelic-induced brain states reorganize visual information processing from single neurons to large-scale neural populations.
Objectives and Approach
Investigate relationships between neural population dynamics and behavioral variables including pupil diameter, eye movements, locomotion, and facial motion.
Progress and Next Steps
- https://docs.google.com/presentation/d/1N6mjNWEJFlAulMOFRLk9VMuh129uELauWYpnrBZnOoc/edit?usp=sharing
Background and References
Siegel et al. (2024)
Psilocybin desynchronizes the human brain.
Tylor, C. et al.
“Psilocybin alters cortical dynamics and behavior in mice.”